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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and it's potential costs to the body was born

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Interestingly, early 20th-century packs often held 10, 12, or even 14 cigarettes the 20-count only became dominant after World War II

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